姓名 | 翟振亚 |
|
职称/职务 | 副研究员/副所长(聘用) | |
e-mail:
| ||
电话: | 15813318526 |
研究领域:
1.肠道干细胞发育及肠道健康研究;
2.胆汁酸对细胞代谢的调控机制研究。
3.调控肠道健康和脂质代谢的药食同源植物食品开发
教育经历:
2010/09–2014/06,华南农业大学,动物科学学院,学士学位
2014/09 - 2019/06,华南农业大学,动物科学学院,博士学位 (导师:印遇龙 院士)
工作经历
2023-至今 江西省科学院生物资源研究所 副研究员/副所长(聘用)
2020-2022 江西省科学院与中科院亚热带农业生态研究所联合培养博士后
2019-2022 江西省科学院生物资源研究所 助理研究员
承担及参与科研项目
[1] 国家自然科学基金(32360854)项目,2024-2027.(在研)
[2] 江西省主要学科带头人(青年项目,20232bcj23049),2024-2026.(在研)
[3] 江西省自然科学基金青年基金(20232bab215056),2024-2026.(在研)
[4] 中国博士后科学基金第68批面上项目资助(2020m682108),2020-2022.(结题)
[5] 江西省重点研发计划一般项目(20203bbfl63054),2020-2022。(结题)
[6] 江西省科学院省级财政科研项目经费包干制试点示范项目(重点研发计划-重点项目,2022ysbg21001),2022-2024(在研)
[7] 江西省科学院省级科研院基础研究项目(2023yjc2001),2023-2024(在研)
[8] 国家自然科学基金项目(32260593)(排名第二,参与,在研)
代表性论著
[1] zhai z*, liu y, niu k, zeng w, wang r, guo x, lin c, hu l. oleanolic acid alleviate intestinal inflammation by inhibiting takeda g-coupled protein receptor (tgr) 5 mediated cell apoptosis. food funct. 2024 feb 19;15(4):1963-1976. doi: 10.1039/d3fo04882a. pmid: 38275075.(第一/通讯作者,中科院1区,top期刊)
[2] zhu m, lin c, niu k, liu y, zeng w, wang r, guo x, zhai z*. bile acid metabolic profiles and their correlation with intestinal epithelial cell proliferation and barrier integrity in suckling piglets. animals (basel). 2024 jan 17;14(2):287. doi: 10.3390/ani14020287. pmid: 38254456; pmcid: pmc10812516.(jcr 1区,if=5.64)
[3] liu y, niu k, wang r, liang x, lin c, wu x, zhai z*. taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid x receptor. food funct. 2023 jun 6;14 (11):5277-5289. doi: 10.1039/d3fo00770g. pmid: 37195071. (通讯作者,中科院1区,top期刊)
[4] zhai z, niu k m, liu y et al. the gut microbiota-bile acids-tgr5 axis mediates eucommia ulmoides leaf extract alleviation of injury to colonic epithelium integrity[j]. front microbiol, 2021,12:727681.(jcr 1区,if=5.64)
[5] zhai z, liu j, niu k-m, lin c, tu y, liu y, cai l, liu h and ouyang k (2021) integrated metagenomics and metabolomics to reveal the effects of policosanol on modulating the gut microbiota and lipid metabolism in hyperlipidemic c57bl/6 mice. front. endocrinol. 12:722055. doi: 10.3389/fendo.2021.722055 (jcr1区,if=5.55)
[6] zhai z, niu k-m, liu h et al. policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in c57bl6/mice through ampk–fxr–tgr5 cross-talk. j. fodo sci. 2021;1–13.doi: 10.1111/1750-3841.15951(jcr2区,if=3.167)
[7] zhai z, zhang f, cao r et al. cecropin a alleviates inflammation through modulating the gut microbiota of c57bl/6 mice with dss-induced ibd[j]. front microbiol, 2019,10(jcr1区,if=4.32).
[8] zhai z, ni x, jin c et al. cecropin a modulates tight junction-related protein expression and enhances the barrier function of porcine intestinal epithelial cells by suppressing the mek/erk pathway[j]. int j mol sci, 2018,19(7). (jcr1区,if=3.6)
[9] 翟振亚, 胡小超, 高春起 等. 日粮添加二甲酸钾和凝结芽孢杆菌对断奶仔猪生长性能和免疫指标的影响[j]. 饲料工业, 2015,36(12):8-11.
[10] chengquan t, zhenya z, xiaojun n et al. metabolomic profiles reveal potential factors that correlate with lactation performance in sow milk[j]. sci rep-uk, 2018,8(1).
[11] chen j, zhai z, long h et al. inducible expression of defensins and cathelicidins by nutrients and associated regulatory mechanisms[j]. peptides, 2020,123.
[12] ni x, zhai z, xin z et al. antioxidant properties and transepithelial transportation of di-/tripeptides derived from simulated gastrointestinal digestion of pig blood cells hydrolysates[j]. efood, 2020,1(3).
[13] xin z, zhai z, long h et al. metabolic profiling by uplc-orbitrap-ms/ms of liver from c57bl/6 mice with dss-induced inflammatory bowel disease[j]. mediators inflamm, 2020,2020:6020247.
[14] fan h b, zhai z, li x g et al. cdx2 stimulates the proliferation of porcine intestinal epithelial cells by activating the mtorc1 and wnt/beta-catenin signaling pathways[j]. int j mol sci, 2017,18(11).
[15] li x, zhu m, chen m...zhai z et al. acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the wnt/beta-catenin pathway[j]. toxicol lett, 2019,305:19-31.
[16] deng b, ni x, zhai z et al. new quantitative structure-activity relationship model for angiotensin-converting enzyme inhibitory dipeptides based on integrated descriptors[j]. j agric food chem, 2017,65(44):9774-9781.
[17] 唐天悦, 翟振亚, 谭成全 等. 半胱胺在猪营养上的研究进展[j]. 动物营养学报, 2018,30(05):1647-1654.
[18] 金成龙, 翟振亚, 王丹 等. 甘氨酸铜替代硫酸铜对断奶仔猪生长性能、血清生化参数和粪铜排放的影响[j]. 广东农业科学, 2015,42(01):100-104.